Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12313/556
Title: Gastroprotective effects of new diterpenoid derivatives from Azorella cuatrecasasii Mathias & Constance obtained using a β-cyclodextrin complex with microbial and chemical transformations
Authors: Sepúlveda, Beatriz
Quispe, Cristina
Simirgiotis, Mario
García-Beltrán, Olimpo
Areche, Carlos
Keywords: Azorella cuatrecasasii
Biotransformation
Microbial transformation
Mulinane
Gastric ulcer
Issue Date: 15-Jul-2016
Publisher: Bioorganic And Medicinal Chemistry Letters
Citation: Sepúlveda, B., Quispe, C., Simirgiotis, M., García-Beltrán, O., & Areche, C. (2016). Gastroprotective effects of new diterpenoid derivatives from Azorella cuatrecasasii Mathias & Constance obtained using a β-cyclodextrin complex with microbial and chemical transformations. Bioorganic & Medicinal Chemistry Letters, 26(14), 3220–3222.
Abstract: Mulinane diterpenoids isolated from Azorella species have displayed gastroprotective effects in animal models. In this study we have transformed the main constituent, mulin-11,13-dien-20 oic acid from this plant using the filamentous fungus Mucor plumbeus and a β-cyclodextrin inclusion complex and we have obtained two main products with good yields (33% and 15% for compound 4 and 5, respectively) for further preparation of semisynthetic derivatives to evaluate their gastroprotective effects. In addition, one of the compounds isolated from Azorella cuatrecasasii was new (9-epi-13α-hydroxymulinene 1). Six new derivatives 4a–4c and 5a–5c were then prepared by simple chemical transformations. The structures of all compounds were elucidated by spectroscopic means based on 1D and 2D-NMR techniques. Some 8 diterpenes were evaluated for their gastroprotective effects in the ethanol/HCl-induced ulcer model in mice at 20 mg/kg. The highest gastroprotective activity was shown by 7α,16-dihydroxymulin-11,13-dien-20-oic acid 5, which was higher than the reference drug lansoprazole, while 16-hydroxymulin-11,13-dien-20-oic acid 4 was as active as lansoprazole.
URI: https://www.sciencedirect.com/science/article/pii/S0960894X16305935?via%3Dihub
ISSN: 0960-894X
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