Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12313/496
Title: Gastroprotective activity of synthetic coumarins: Role of endogenous prostaglandins, nitric oxide, non-protein sulfhydryls and vanilloid receptors
Authors: Sepúlveda, Beatriz
Quispe, Cristina
Simirgiotis, Mario
Torres-Benítez, Alfredo
Reyes-Ortíz, Johanna
Areche, Carlos
García-Beltrán, Olimpo
Keywords: Coumarins
Gastroprotective
Ulcer
Heterocycles
Issue Date: 21-Nov-2016
Publisher: Bioorganic & Medicinal Chemistry Letters
Citation: Sepulveda, B., Quispe, C., Simirgiotis, M., Torres-Benítez, A., Reyes-Ortíz, J., Areche, C., & García-Beltrán, O. (2016). Gastroprotective activity of synthetic coumarins: Role of endogenous prostaglandins, nitric oxide, non-protein sulfhydryls and vanilloid receptors. Bioorganic & Medicinal Chemistry Letters, 26(23), 5732–5735.
Abstract: Natural or synthetic coumarins showed gastroprotective and antiulcer activity in animal models. In this study, we have synthetized twenty coumarins using classic methods to evaluate their gastroprotective effects on the ethanol/HCl-induced gastric lesion model in mice at 20 mg/kg. Among the coumarins synthetized, compounds 6 and 10 showed the greatest gastroprotective activity being as active as lansoprazole at 20 mg/kg and reducing gastric lesions by 75 and 76%, respectively. Then, in a second experiment, compounds 6 and 10 were re-evaluated in order to understand the possible mode of gastroprotective activity. Regarding coumarin 6, the protective effect was reduced by pre-treatment of the mice with N-ethylmaleimide and l-NAME suggesting that sulfhydryl compounds and endogenous nitric oxide are involved in its gastroprotective activity. While for coumarin 10 the effect was reduced by pre-treatment with indomethacin suggesting that prostaglandins are positively involved in its gastroprotective activity.
URI: https://www.sciencedirect.com/science/article/pii/S0960894X16310940?via%3Dihub
ISSN: 0960-894X
Appears in Collections:Artículos

Files in This Item:
There are no files associated with this item.



Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.