Publicación:
Chemical Profiling and Cholinesterase Inhibitory Activity of Five Phaedranassa Herb. (Amaryllidaceae) Species from Ecuador

dc.contributor.authorMoreno, Raúl
dc.contributor.authorTallini, Luciana R.
dc.contributor.authorSalazar, Cristina
dc.contributor.authorOsorio, Edison
dc.contributor.authorMontero, Evelin
dc.contributor.authorBastida, Jaume
dc.contributor.authorOleas, Nora H.
dc.contributor.authorAcosta León, Karen
dc.date.accessioned2020-09-16T14:43:42Z
dc.date.available2020-09-16T14:43:42Z
dc.date.issued2020-04-30
dc.description.abstractIt is estimated that 50 million people in the world live with dementia, 60–70% of whom suffer from Alzheimer’s disease (AD). Different factors are involved in the development of AD, including a reduction in the cholinergic neurotransmission level. The Amaryllidaceae plant family contains an exclusive, large, and still understudied alkaloid group characterized by a singular skeleton arrangement and a broad spectrum of biological activities. The chemistry and biodiversity of Ecuadorian representatives of the Phaedranassa genus (Amaryllidaceae) have not been widely studied. In this work, five Ecuadorian Phaedranassa species were examined in vitro for their activity towards the enzymes acetyl- (AChE) and butyrylcholinesterase (BuChE), and the alkaloid profile of bulb extracts was analyzed by GC-MS. The species Phaedranassa cuencana and Phaedranassa dubia showed the most AChE and BuChE inhibitory activity, respectively. To obtain insight into the potential role of the identified alkaloids in these inhibitory effects, docking experiments were carried out, and cantabricine showed in silico inhibitory activity against both cholinesterase structures. Our results show that Amaryllidaceae species from Ecuador are a potential source of new drugs for the palliative treatment of AD.es_CO
dc.description.sponsorshipUniversidad de Ibaguées_CO
dc.identifier.citationMoreno, R.; Tallini, L.R.; Salazar, C.; Osorio, E.H.; Montero, E.; Bastida, J.; Oleas, N.H.; Acosta León, K. Chemical Profiling and Cholinesterase Inhibitory Activity of Five Phaedranassa Herb. (Amaryllidaceae) Species from Ecuador. Molecules 2020, 25, 2092.es_CO
dc.identifier.issn1420-3049
dc.identifier.urihttps://www.mdpi.com/1420-3049/25/9/2092
dc.language.isoenes_CO
dc.publisherMoleculeses_CO
dc.subjectAlkaloidses_CO
dc.subjectAmaryllidaceaees_CO
dc.subjectCholinesteraseses_CO
dc.subjectGC-MSes_CO
dc.subjectMolecular dockinges_CO
dc.subjectPhaedranassaes_CO
dc.titleChemical Profiling and Cholinesterase Inhibitory Activity of Five Phaedranassa Herb. (Amaryllidaceae) Species from Ecuadores_CO
dc.typeArticlees_CO
dspace.entity.typePublication
eperson.emailedison.osorio@unibague.edu.coes_CO
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