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Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations

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dc.contributor.authorNagles, Edgar
dc.contributor.authorMurcia, Ricardo A.
dc.contributor.authorLeal, Sandra M.
dc.contributor.authorRoa, Martha V.
dc.contributor.authorMuñoz-Castro, Alvaro
dc.contributor.authorHurtado, John
dc.date.accessioned2018-09-13T19:56:07Z
dc.date.available2018-09-13T19:56:07Z
dc.date.issued2018-08-13
dc.description.abstractIn this work, six complexes (2⁻7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3⁻7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL-1. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities.es_CO
dc.identifier.citationMurcia, R., Leal, S., Roa, M., Nagles, E., Muñoz-Castro, A., & Hurtado, J. (2018). Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations. Molecules, 23(8), 2013. doi:10.3390/molecules23082013es_CO
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/20.500.12313/144
dc.identifier.urihttp://www.mdpi.com/1420-3049/23/8/2013
dc.language.isoenes_CO
dc.publisherNCBIes_CO
dc.relation.ispartofseriesMolecules;23
dc.subjectAntibacterial activityes_CO
dc.subjectAntifungal activityes_CO
dc.subjectCobalt(II) and chromium(III) complexeses_CO
dc.subjectTriazole ligandses_CO
dc.titleDevelopment of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluationses_CO
dc.typeArticlees_CO
dspace.entity.typePublication
eperson.emailedgar.nagles@unibague.edu.co
eperson.emailjose.garcia@unibague.edu.co
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