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Development of a microcomposite with single-walled carbon nanotubes and Nd2O3 for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry

dc.contributor.authorGarcía-Beltrán, Olimpo
dc.contributor.authorNagles, Edgar
dc.contributor.authorPenagos-Llanos, Johisner
dc.contributor.authorArancibia, Verónica
dc.contributor.authorHurtado, John
dc.date.accessioned2019-02-28T14:06:03Z
dc.date.available2019-02-28T14:06:03Z
dc.date.issued2018-11-22
dc.description.abstractThis study presents for the first time a new composite of carbon paste (CP), single-walled carbon nanotubes (SWCNTs) and Nd2O3 (NdOX). This versatile composite (NdOX-SWCNT/CPE) was applied to the oxidation of paracetamol (PCM). The newly formed surface was characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The results showed greater conductivity and a higher surface area for the composite than those of the carbon paste alone. Moreover, the anodic peak currents for PCM increased from 1.6 to 3.6 µA with CPE and NdOX-SWCNT/CPE, indicating an increase of nearly 51.0% for the anodic peak current. On the other hand, the anodic peak potentials shifted from 0.67 to 0.57 V. The detection limits were 0.05 µmol/L with NdOX-SWCNT/CPE and 0.50 µmol/L with SWCNT/CPE. The relative standard deviations (RSDs) were 1.5% (n = 7). The accuracy and interference of the methods were evaluated with a urine chemistry control spiked with known quantities of PCM, uric acid, dopamine, ascorbic acid, caffeine, acetylsalicylic acid, tartrazine, sunset yellow, allure red, rutin, morin and metal ions. Finally, the novelty and usefulness of the composite were evaluated to quantify PCM in pharmaceutical dosage forms such as tablets, powders and syrups for children.es_CO
dc.identifier.citationArancibia, V., Penagos-Llanos, J., Nagles, E., García-Beltrán, O., & Hurtado, J. J. (2019). Development of a microcomposite with single-walled carbon nanotubes and Nd2O3 for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry. Journal of Pharmaceutical Analysis, 9(1), 62–69.es_CO
dc.identifier.issn2095-1779
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S20951779183038733
dc.language.isoenes_CO
dc.publisherJournal of Pharmaceutical Analysises_CO
dc.subjectParacetamoles_CO
dc.subjectNeodymium (III) Oxidees_CO
dc.subjectSingle-walled carbon nanotubeses_CO
dc.subjectPharmaceutical dosagees_CO
dc.titleDevelopment of a microcomposite with single-walled carbon nanotubes and Nd2O3 for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetryes_CO
dc.typeArticlees_CO
dspace.entity.typePublication
eperson.emailjose.garcia@unibague.edu.coes_CO
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