Examinando por Autor "Gómez, Marisol"
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- PublicaciónSólo datosDetection of SO2 derivatives using a new chalco-coumarin derivative in cationic micellar media: application to real samples(The Royal Society of Chemistry, 2018-09-05) García-Beltrán, Olimpo; Gómez, Marisol; Aliaga, Margarita E.; Edgar, Nagles; Arancibia, Verónica; Moya, Alexis; Segura, Camilo; Núñez, Marco T.; Aguirre, PablaA new probe (E)-7-(diethylamino)-3-(3-(thiophen-2-yl)acryloyl)-2H-chromen-2-one (ChC16) was synthesized and studied as a turn-on fluorescent probe, based on a Michael addition mechanism for sensing SO2 derivatives, which is favored in the presence of cationic micellar media such as cetylpyridinium bromide (CPB). The probe showed high selectivity and sensitivity toward bisulfite over other anions and biothiols, including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), with a detection limit of 240 nM. Moreover, the probe showed great potential for its practical application in the detection of bisulfite in real samples, such as dry white wine, and in bioimaging.
- PublicaciónSólo datosNew fluorescent turn-off probes for highly aensitive and selective detection of SO2derivatives in a micellar media(Sensors and Actuators B: Chemical, 2017-01-20) Gómez, Marisol; Perez, Edwin G.; Arancibia, Verónica; Iribarren, Constanza; Bravo-Díaz, Carlos; García-Beltrán, Olimpo; Aliaga, Margarita E.In this work, two isoxazole derivatives (1 and 2) were synthesized and characterized using common spectroscopic tools. The chemosensor behavior of 1 and 2 toward various analytes was explored and we found that both probes follow a ‘switch-off’ mechanism during SO2-derivatives sensing, with limits of detection near 10−6 and 10−5 M, respectively. A recognition mechanism is proposed, based on a Michael-type addition reaction toward the probes, induced by SO2-derivatives and favored by micellar media. Typical interferences like glutathione (GSH) and cysteine (Cys) were inhibited by the presence of the cationic micelles of cetylpyridinium bromide (CPB) and the zwitterionic micelle of sulfobetaine (SB3-14); the detection limits were considerably improved. Thus, on the basis of these results, it is suggested that the use of these kinds of surfactants can be considered as a strategy for optimizing the detection of sulfite via its addition reaction to activated olefins containing isoxazole. Finally, probe 1 was chosen as the best sensor since it was assessed to detect SO2-derivatives in real samples (red and white wines) and in a biological system (Caco-2 cells) with very good results.
- PublicaciónSólo datosNew fluorescent turn-off probes for highly aensitive and selective detection of SO2derivatives in a micellar media(Sensors and Actuators B: Chemical, 2017-01-20) Gómez, Marisol; Pérez, Edwin G.; Arancibia, Verónica; Iribarren, Constanza; Bravo-Díaz, Carlos; García-Beltrán, Olimpo; Aliaga, Margarita E.In this work, two isoxazole derivatives (1 and 2) were synthesized and characterized using common spectroscopic tools. The chemosensor behavior of 1 and 2 toward various analytes was explored and we found that both probes follow a ‘switch-off’ mechanism during SO2-derivatives sensing, with limits of detection near 10−6 and 10−5 M, respectively. A recognition mechanism is proposed, based on a Michael-type addition reaction toward the probes, induced by SO2-derivatives and favored by micellar media. Typical interferences like glutathione (GSH) and cysteine (Cys) were inhibited by the presence of the cationic micelles of cetylpyridinium bromide (CPB) and the zwitterionic micelle of sulfobetaine (SB3-14); the detection limits were considerably improved. Thus, on the basis of these results, it is suggested that the use of these kinds of surfactants can be considered as a strategy for optimizing the detection of sulfite via its addition reaction to activated olefins containing isoxazole. Finally, probe 1 was chosen as the best sensor since it was assessed to detect SO2-derivatives in real samples (red and white wines) and in a biological system (Caco-2 cells) with very good results.